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Tocris Bioscience™ Wnt-C59
Highly potent PORCN inhibitor
€ 389.00 - € 1470.00
Specifications
| Purity | >99% |
|---|---|
| Product Type | Wnt-C59 |
| Molecular Weight (g/mol) | 379.45 |
| Inhibitors | Wnt-C59 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18702459
|
Tocris Bioscience™
5148/10 |
10 mg |
€ 389.00
10mg |
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|
18735708
|
Tocris Bioscience™
5148/50 |
50 mg |
€ 1470.00
50mg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
Wnt-C59 is a highly potent inhibitor of MBOAT (membrane-bound O-acyltranferase) family member Porcupine (PORCN) (IC50 = 74 pM) that mediates WNT palmitoylation and secretion. Wnt-C59 potently inhibits the processing of both canonical (1, 2, 3a, 6, 7b, 8a, 9a, 9b, 10) and non-canonical (4, 5a, 11, 16) Wnt subtypes. Wnt-C59 blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/β-catenin target genes. Wnt-C59 treated tumors show a decrease in β-catenincatenin, CyclinD1 and c-Myc. Wnt-C59 induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021 (Cat. No. 4423). Wnt-C59 efficiently induces neural differentiation of CTIP2+/COUP-TF1- cells from PSCs in culture. When grafted into the cortex of adult mice, develop abundant axonal fiber extension toward the spinal cord. Cell permeable and orally bioavailable.Specifications
| >99% | |
| Wnt-C59 | |
| 379.45 | |
| Wnt-C59 |
For Research Use Only