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Tocris™ VCP 171

Positive allosteric modulator (PAM) of A1 receptors; also allosteric partial agonist in absence of orthosteric agonist

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Specifications

Chemical Name or Material [2-Amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenylmethanone
CAS 1018830-99-3
Target Adenosine A1 Receptor Modulators
Molecular Formula C18H12F3NOS
Purity 0.98
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Description

Description

VCP 171 is an adenosine A1 receptor positive allosteric modulator (PAM) (pKB = 5.65, binding cooperativity with NECA 0.68). In absence of orthosteric agonist, VCP171 behaves as an allosteric partial agonist, inhibiting cAMP activity. Inhibits AMPA receptor-mediated evoked excitatory postsynaptic current (eEPSC) amplitude in lamina I and II neurons in a rat partial nerve-injury model of neuropathic pain.
Specifications

Specifications

[2-Amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenylmethanone
Adenosine A1 Receptor Modulators
0.98
1018830-99-3
C18H12F3NOS
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Recommended Storage : Store at -20°C

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