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Tocris™ VCP 171
Positive allosteric modulator (PAM) of A1 receptors; also allosteric partial agonist in absence of orthosteric agonist
Brand: Tocris™ 6261/10
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Description
VCP 171 is an adenosine A1 receptor positive allosteric modulator (PAM) (pKB = 5.65, binding cooperativity with NECA 0.68). In absence of orthosteric agonist, VCP171 behaves as an allosteric partial agonist, inhibiting cAMP activity. Inhibits AMPA receptor-mediated evoked excitatory postsynaptic current (eEPSC) amplitude in lamina I and II neurons in a rat partial nerve-injury model of neuropathic pain.Specifications
| [2-Amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenylmethanone | |
| 10 mg | |
| C18H12F3NOS |
| 1018830-99-3 | |
| Adenosine A1 Receptor Modulators | |
| 0.98 |