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Phenylethyl 3,4-dihydroxycinnamate, 98+%, Thermo Scientific Chemicals Product Code.: 15493989
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Phenylethyl 3,4-dihydroxycinnamate, 98+%, Thermo Scientific Chemicals

Product Code. 15493989
250 mg
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Quantity:
250 mg
1 g
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Product Code. 15493989

Brand: Thermo Scientific Alfa Aesar J61386.MD

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Description

Inhibitor of protein tyrosine kinase, and is cytotoxic to cancer cell lines

Phenylethyl 3,4-dihydroxycinnamate is a potent and specific inhibitor of nuclear transcription factor, NF-κB, activation. It has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. It inhibits HIV-1 integrase and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Phenylethyl 3,4-dihydroxycinnamate is a potent and specific inhibitor of nuclear transcription factor, NF-κB, activation. It has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. It inhibits HIV-1 integrase and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.

Solubility
Soluble in ethyl acetate at 50mg/ml. Soluble in DMSO and ethanol.

Notes
Light sensitive. Incompatible with oxidizing agents and heat.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 104594-70-9
Molecular Formula C17H16O4
Molecular Weight (g/mol) 284.31
MDL Number MFCD00866470
InChI Key SWUARLUWKZWEBQ-VQHVLOKHSA-N
Synonym caffeic acid phenethyl ester, phenethyl caffeate, cape, capeee, phenethyl 3-3,4-dihydroxyphenyl acrylate, phenylethyl caffeate, unii-g960r9s5sk, caffeic acid phenylethyl ester, 2-phenylethyl caffeate, caffeic acid 2-phenylethyl esterShow MoreShow Less
PubChem CID 5281787
ChEBI CHEBI:8062
IUPAC Name 2-phenylethyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
SMILES OC1=CC=C(\C=C\C(=O)OCCC2=CC=CC=C2)C=C1O

Specifications

Melting Point 127°C to 129°C
Color White to Yellow
Quantity 250 mg
Sensitivity Light sensitive
Solubility Information Soluble in ethyl acetate at 50mg/ml; Soluble in DMSO and ethanol.
Formula Weight 284.31
Percent Purity ≥99%
Physical Form Crystalline Powder
Chemical Name or Material Phenylethyl 3,4-dihydroxycinnamate

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3 results found
Lot Number Certificate Type Date Catalog Number
Lot NumberU06H024 Certificate TypeCertificate of Analysis Date07/12/2021 Catalog NumberJ61386.MD,J61386.03
Lot NumberF28X215 Certificate TypeCertificate of Analysis Date07/12/2021 Catalog NumberJ61386.MD,J61386.03
Lot NumberQ04F023 Certificate TypeCertificate of Analysis Date07/12/2021 Catalog NumberJ61386.MD,J61386.03

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