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Invitrogen™ Human CXCR4 Synthetic Peptide

Synthetic Peptide

Brand:  Invitrogen™ PEP0002

94.00 EUR valid until 2025-03-21
Use promo code "24111" to get your promotional price.


Product Code. 15246229

  • € 141.00 / 50µg

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To receive the discount customers must purchase three of the same product at list price in a single order to receive 33% discount. There is no limit to the multiples of 3 that customers can buy. Use promo code ”24111” to get your promotional price

This item is not returnable. View return policy

Description

Description

CXCR4 Synthetic Peptide, PEP-0002, from Invitrogen.

CXCR4 (Fusin, LESTR, HUMSTR) is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a co-receptor for X4 HIV-1 entry into CD4+ cells. CXCR4 has been proved to be the co-receptor for HIV-2's binding to CD4 through envelope glycoprotein gp 120 and promotes Env-mediated fusion of the virus. In other cases, CXCR4 can even function as the only receptor for HIV-2's binding to the CD4 host cells. CXCR4 is the receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. CXCR4 acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Also, CXCR4 is involved in hematopoiesis and in cardiac ventricular septum formation, and plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. In the CNS, CXCR4 could mediate hippocampal-neuron survival and is involved in cerebellar development. CXCR4 binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV biding sites.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

7852
purified
Human CXCR4
-20°C
Liquid
Blocking Assay, Control
No
Peptide
RUO - research use only
Human
P61073
200 μg/mL
Synthetic Peptide
PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
CXCR4
0.02% sodium azide
50 μg
PBS
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Product Title
Invitrogen™ Human CXCR4 Synthetic Peptide > 50 μg; Unlabeled

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