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Tocris Bioscience™ FRAX 486

Potent PAK inhibitor; brain penetrant and orally bioavailable

€ 285.00

Specifications

Purity >98%
Product Type FRAX 486
Molecular Weight (g/mol) 513.39
Inhibitors FRAX 486
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Product Code Brand Quantity Price Quantity & Availability  
18711678
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Tocris Bioscience™
5190/10 		10 mg
€ 285.00
10mg
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Description

Description

Potent p21-activated kinase (PAK) inhibitor (IC50 values are 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively). Blocks and reverses the DISC1 knockdown-induced reduction in dendritic spine size in cortical neurons. Attenuates dendritic spine elimination and enhances spine generation in DISC1 knockdown mice. Ameliorates autism-like behavioral symptoms in fragile X mental retardation 1 (Fmr1) knockout mice. Brain penetrant and orally bioavailable.
Specifications

Specifications

>98%
FRAX 486
513.39
FRAX 486
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