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Tocris Bioscience™ FRAX 486

Potent PAK inhibitor; brain penetrant and orally bioavailable

Brand:  Tocris Bioscience™ 5190/10

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Product Code. 18711678

  • € 285.00 / 10mg

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Description

Description

FRAX 486 is a potent p21-activated kinase (PAK) inhibitor (IC50 values are 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively). Blocks and reverses the DISC1 knockdown-induced reduction in dendritic spine size in cortical neurons. Attenuates dendritic spine elimination and enhances spine generation in DISC1 knockdown mice. Ameliorates autism-like behavioral symptoms in fragile X mental retardation 1 (Fmr1) knockout mice. Brain penetrant and orally bioavailable.
Specifications

Specifications

>98%
FRAX 486
FRAX 486
10 mg
513.39
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