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BX 471, Tocris Bioscience™

Artikelnummer. 30001487
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Quantity:
10 mg
50 mg
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Beschreibung

Potent, selective CCR1 antagonist

Potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1). Exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. Inhibits MIP-α/CCL3-induced intracellular Ca2+ mobilization. Orally active; effectively reduces disease severity in a rat model of multiple sclerosis. Decreases renal fibrosis in a mouse model of obstructive nephropathy.

Chemische Identifikatoren

CAS 217645-70-0
Molecular Formula C21H24ClFN4O3
Molecular Weight (g/mol) 434.896
InChI Key XQYASZNUFDVMFH-CQSZACIVSA-N
Synonym ZK-811752, unii-76k17zg4zn, r-1-5-chloro-2-2-4-4-fluorobenzyl-2-methylpiperazin-1-yl-2-oxoethoxy phenyl urea, 5-chloro-2-2-2r-4-4-fluorophenyl methyl-2-methylpiperazin-1-yl-2-oxoethoxy phenyl urea, n-5-chloro-2-2-2r-4-4-fluorophenyl methyl-2-methyl-1-piperazinyl-2-oxoethoxy phenyl-urea, urea, n-5-chloro-2-2-2r-4-4-fluorophenyl methyl-2-methyl-1-piperazinyl-2-oxoethoxy phenyl, bx-471free base, d05xzf, gtpl767
PubChem CID 512282
IUPAC Name [5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]urea
SMILES CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F

Spezifikation

Quantity 50 mg
Formula Weight 434.89
Percent Purity >98%
Chemical Name or Material BX 471
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