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STEMCELL Technologies AM580

Retinoid pathway activator; Activates retinoic acid receptor (RAR) alpha

POA - € 260.55

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Product Code	Brand	Quantity	Price	Quantity & Availability
Product Code	Brand	Quantity	Price	Quantity & Availability
17140152 View Documents Promotion Details missing translation for 'viewProductCertificates'	STEMCELL Technologies 72962	1 mg	POA 1mg View alternative products Save Up to »	N/A	Please sign in to purchase this item. Need a web account? Register with us today!
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17150152 View Documents Promotion Details missing translation for 'viewProductCertificates'	STEMCELL Technologies 72964	10 mg	€ 260.55 10mg View alternative products Save Up to »		Please sign in to purchase this item. Need a web account? Register with us today!

Description

AM580 is a retinoic acid receptor (RAR) agonist that is selective for RARα (EC₅₀ = 0.36 nM) compared to RARβ (EC₅₀ = 24.6 nM) and RARγ (EC₅₀ = 27.9 nM; Bernard et al.) It is a derivative of retinoic acid (RA), however it demonstrates greater specific binding to RARα compared to RA, which exhibits little selectivity across RARα, β, or γ (Gianní et al.; Bernard et al.; Kim et al; Rochette-Egly & Germain)
Promotes reprogramming of somatic cells to induced pluripotent stem cells (Wang et al.)
Induces differentiation of human induced pluripotent stem cells into intermediate mesoderm, in combination with the GSK3β inhibitor CHIR99021 (Araoka et al.)
Inhibits tumor cell proliferation and survival signaling pathways, and induces apoptosis, leading to inhibition of mouse mammary tumor virus (MMTV)-neu- and MMTV-wnt1-induced mammary gland hyperplasia (Lu et al.)
Inhibits tumor growth in MMTV-Myc mice (Bosch et al.)
Inhibits endometrial cancer cell proliferation (Cheng et al.)
Induces differentiation in acute promyelocytic leukemia cells (Gianní et al.)

Specifications

Description