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STEMCELL Technologies AM580
Retinoid pathway activator; Activates retinoic acid receptor (RAR) alpha
Brand: STEMCELL Technologies 72964
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Description
- AM580 is a retinoic acid receptor (RAR) agonist that is selective for RARα (EC50 = 0.36 nM) compared to RARβ (EC50 = 24.6 nM) and RARγ (EC50 = 27.9 nM; Bernard et al.) It is a derivative of retinoic acid (RA), however it demonstrates greater specific binding to RARα compared to RA, which exhibits little selectivity across RARα, β, or γ (Gianní et al.; Bernard et al.; Kim et al; Rochette-Egly & Germain)
- Promotes reprogramming of somatic cells to induced pluripotent stem cells (Wang et al.)
- Induces differentiation of human induced pluripotent stem cells into intermediate mesoderm, in combination with the GSK3β inhibitor CHIR99021 (Araoka et al.)
- Inhibits tumor cell proliferation and survival signaling pathways, and induces apoptosis, leading to inhibition of mouse mammary tumor virus (MMTV)-neu- and MMTV-wnt1-induced mammary gland hyperplasia (Lu et al.)
- Inhibits tumor growth in MMTV-Myc mice (Bosch et al.)
- Inhibits endometrial cancer cell proliferation (Cheng et al.)
- Induces differentiation in acute promyelocytic leukemia cells (Gianní et al.)
Specifications
| 102121-60-8 | |
| 10 mg | |
| ≥98% |
| CD336; NSC 608001; Ro 40-6055 | |
| C22H25NO3 |