accessibility menu, dialog, popup

Test

Amino Acids

Amino Acids

Organic compounds composed of a central carbon atom, a carboxyl group, an amino group, and a unique side chain; precursors to other molecules including proteins, hormones, and neurotransmitters.
Molecular Weight (g/mol) 
  • (1)
  • (25)
  • (3)
  • (3)
  • (3)
  • (2)
  • (4)
  • (3)
  • (1)
Quantity 
  • (7)
  • (1)
  • (2)
  • (7)
  • (1)
  • (1)
  • (8)
  • (1)
  • (1)
  • (4)
  • (8)
  • (2)
  • (1)
  • (1)
Percent Purity 
  • (3)
  • (1)
  • (3)
  • (3)
  • (1)
  • (13)
  • (1)
  • (12)
Grade 
  • (2)
  • (2)
  • (1)
Keyword Search: isoleucine Clear all selections

Filtered Search Results

Products from some of our suppliers do not display in filtered search results. Please clear all filters to see these products.

Narrow Results

Selected Filters

Clear all

Keyword Search

isoleucine

Narrow Results

Narrow Results

No results found within this category. Try removing some selected filters and try again.

category

brands

  • (1)
  • (1)
  • (2)
  • (1)
  • (1)
  • (6)
  • (33)

special offers

  • (6)

Molecular Weight (g/mol)

  • (1)
  • (25)
  • (3)
  • (3)
  • (3)
  • (2)
  • (4)
  • (3)
  • (1)

Quantity

  • (7)
  • (1)
  • (2)
  • (7)
  • (1)
  • (1)
  • (8)
  • (1)
  • (1)
  • (4)
  • (8)
  • (2)
  • (1)
  • (1)

Percent Purity

  • (3)
  • (1)
  • (3)
  • (3)
  • (1)
  • (13)
  • (1)
  • (12)

Grade

  • (2)
  • (2)
  • (1)
1 – 15 of 19 results
1

Thermo Scientific Chemicals L-Isoleucine, 99%

CAS: 73-32-5 Molecular Formula: C6H13NO2 Molecular Weight (g/mol): 131.18 MDL Number: MFCD00064222 MFCD00004268 InChI Key: AGPKZVBTJJNPAG-WHFBIAKZSA-N Synonym: l-isoleucine,isoleucine,2s,3s-2-amino-3-methylpentanoic acid,s-isoleucine,s,s-isoleucine,2s,3s-isoleucine,2-amino-3-methylvaleric acid,erythro-l-isoleucine,l-+-isoleucine,l-ile PubChem CID: 6306 ChEBI: CHEBI:17191 IUPAC Name: (2S,3S)-2-amino-3-methylpentanoic acid SMILES: CC[C@H](C)[C@H](N)C(O)=O

Promotions are available
PubChem CID 6306
CAS 73-32-5
Molecular Weight (g/mol) 131.18
ChEBI CHEBI:17191
MDL Number MFCD00064222 MFCD00004268
SMILES CC[C@H](C)[C@H](N)C(O)=O
Synonym l-isoleucine,isoleucine,2s,3s-2-amino-3-methylpentanoic acid,s-isoleucine,s,s-isoleucine,2s,3s-isoleucine,2-amino-3-methylvaleric acid,erythro-l-isoleucine,l-+-isoleucine,l-ile
IUPAC Name (2S,3S)-2-amino-3-methylpentanoic acid
InChI Key AGPKZVBTJJNPAG-WHFBIAKZSA-N
Molecular Formula C6H13NO2
2

Thermo Scientific Chemicals L-Isoleucine, 99%

CAS: 73-32-5 Molecular Formula: C6H13NO2 Molecular Weight (g/mol): 131.18 MDL Number: MFCD00064222 MFCD00004268 InChI Key: AGPKZVBTJJNPAG-WHFBIAKZSA-N Synonym: l-isoleucine,isoleucine,2s,3s-2-amino-3-methylpentanoic acid,s-isoleucine,s,s-isoleucine,2s,3s-isoleucine,2-amino-3-methylvaleric acid,erythro-l-isoleucine,l-+-isoleucine,l-ile PubChem CID: 6306 ChEBI: CHEBI:17191 IUPAC Name: (2S,3S)-2-amino-3-methylpentanoic acid SMILES: CC[C@H](C)[C@H](N)C(O)=O

PubChem CID 6306
CAS 73-32-5
Molecular Weight (g/mol) 131.18
ChEBI CHEBI:17191
MDL Number MFCD00064222 MFCD00004268
SMILES CC[C@H](C)[C@H](N)C(O)=O
Synonym l-isoleucine,isoleucine,2s,3s-2-amino-3-methylpentanoic acid,s-isoleucine,s,s-isoleucine,2s,3s-isoleucine,2-amino-3-methylvaleric acid,erythro-l-isoleucine,l-+-isoleucine,l-ile
IUPAC Name (2S,3S)-2-amino-3-methylpentanoic acid
InChI Key AGPKZVBTJJNPAG-WHFBIAKZSA-N
Molecular Formula C6H13NO2
3

Thermo Scientific Chemicals D-Isoleucine, 98%

CAS: 319-78-8 Molecular Formula: C6H13NO2 Molecular Weight (g/mol): 131.18 MDL Number: MFCD00064221 InChI Key: AGPKZVBTJJNPAG-LXDRQGDMNA-N Synonym: d-isoleucine,2r,3r-2-amino-3-methylpentanoic acid,h-d-ile-oh,isoleucine, d,unii-v87gja0g54,r-isoleucine,2r,3r-2-amino-3-methylvaleric acid,alloisoleucin,d-ile,ambotzhaa1186 PubChem CID: 76551 ChEBI: CHEBI:27730 IUPAC Name: (2R,3R)-2-amino-3-methylpentanoic acid SMILES: CC[C@@H](C)[C@@H](N)C(O)=O

PubChem CID 76551
CAS 319-78-8
Molecular Weight (g/mol) 131.18
ChEBI CHEBI:27730
MDL Number MFCD00064221
SMILES CC[C@@H](C)[C@@H](N)C(O)=O
Synonym d-isoleucine,2r,3r-2-amino-3-methylpentanoic acid,h-d-ile-oh,isoleucine, d,unii-v87gja0g54,r-isoleucine,2r,3r-2-amino-3-methylvaleric acid,alloisoleucin,d-ile,ambotzhaa1186
IUPAC Name (2R,3R)-2-amino-3-methylpentanoic acid
InChI Key AGPKZVBTJJNPAG-LXDRQGDMNA-N
Molecular Formula C6H13NO2
4

Thermo Scientific Chemicals L-Isoleucine, Cell Culture Reagent

CAS: 73-32-5 Molecular Formula: C6H13NO2 Molecular Weight (g/mol): 131.18 MDL Number: MFCD00064222 MFCD00004268 InChI Key: AGPKZVBTJJNPAG-WHFBIAKZSA-N Synonym: l-isoleucine,isoleucine,2s,3s-2-amino-3-methylpentanoic acid,s-isoleucine,s,s-isoleucine,2s,3s-isoleucine,2-amino-3-methylvaleric acid,erythro-l-isoleucine,l-+-isoleucine,l-ile PubChem CID: 6306 ChEBI: CHEBI:17191 IUPAC Name: (2S,3S)-2-amino-3-methylpentanoic acid SMILES: CC[C@H](C)[C@H](N)C(O)=O

PubChem CID 6306
CAS 73-32-5
Molecular Weight (g/mol) 131.18
ChEBI CHEBI:17191
MDL Number MFCD00064222 MFCD00004268
SMILES CC[C@H](C)[C@H](N)C(O)=O
Synonym l-isoleucine,isoleucine,2s,3s-2-amino-3-methylpentanoic acid,s-isoleucine,s,s-isoleucine,2s,3s-isoleucine,2-amino-3-methylvaleric acid,erythro-l-isoleucine,l-+-isoleucine,l-ile
IUPAC Name (2S,3S)-2-amino-3-methylpentanoic acid
InChI Key AGPKZVBTJJNPAG-WHFBIAKZSA-N
Molecular Formula C6H13NO2
5

DL-Isoleucine, 99%, Thermo Scientific Chemicals

CAS: 443-79-8 Molecular Formula: C6H13NO2 Molecular Weight (g/mol): 131.18 MDL Number: MFCD00004268 InChI Key: AGPKZVBTJJNPAG-WHFBIAKZSA-N PubChem CID: 94206 ChEBI: CHEBI:20899 SMILES: CC[C@H](C)[C@H](N)C(O)=O

PubChem CID 94206
CAS 443-79-8
Molecular Weight (g/mol) 131.18
ChEBI CHEBI:20899
MDL Number MFCD00004268
SMILES CC[C@H](C)[C@H](N)C(O)=O
InChI Key AGPKZVBTJJNPAG-WHFBIAKZSA-N
Molecular Formula C6H13NO2
6

D-allo-Isoleucine, 97%, Thermo Scientific Chemicals

CAS: 1509-35-9 Molecular Formula: C6H13NO2 Molecular Weight (g/mol): 131.18 MDL Number: MFCD00066445 InChI Key: AGPKZVBTJJNPAG-CRCLSJGQSA-N Synonym: d-alloisoleucine,d-allo-isoleucine,2r,3s-2-amino-3-methylpentanoic acid,allo-d-isoleucine,alloisoleucine, d,h-d-allo-ile-oh,threo-d-isoleucine,dl-allo-isoleucine,hile,h-dl-allo-ile-oh PubChem CID: 94206 ChEBI: CHEBI:20899 IUPAC Name: (2R,3S)-2-amino-3-methylpentanoic acid SMILES: CC[C@H](C)[C@@H](N)C(O)=O

PubChem CID 94206
CAS 1509-35-9
Molecular Weight (g/mol) 131.18
ChEBI CHEBI:20899
MDL Number MFCD00066445
SMILES CC[C@H](C)[C@@H](N)C(O)=O
Synonym d-alloisoleucine,d-allo-isoleucine,2r,3s-2-amino-3-methylpentanoic acid,allo-d-isoleucine,alloisoleucine, d,h-d-allo-ile-oh,threo-d-isoleucine,dl-allo-isoleucine,hile,h-dl-allo-ile-oh
IUPAC Name (2R,3S)-2-amino-3-methylpentanoic acid
InChI Key AGPKZVBTJJNPAG-CRCLSJGQSA-N
Molecular Formula C6H13NO2
7

N-Fmoc-D-allo-isoleucine, 98%, Thermo Scientific Chemicals

CAS: 118904-37-3 Molecular Formula: C21H23NO4 Molecular Weight (g/mol): 353.42 MDL Number: MFCD00077062 InChI Key: QXVFEIPAZSXRGM-KINVLMLONA-N Synonym: fmoc-d-allo-ile-oh,fmoc-d-allo-isoleucine,fmoc-d-allo-lle-oh,2r,3s-n-fmoc-2-amino-3-methylpentanoic acid,2r,3s-2-9h-fluoren-9-yl methoxy carbonyl amino-3-methylpentanoic acid,d-alloisoleucine, n-9h-fluoren-9-ylmethoxy carbonyl,2r,3s-2-9h-fluoren-9-ylmethoxy carbonyl amino-3-methylpentanoic acid,ambotzfaa1328,pubchem15619 PubChem CID: 6992517 IUPAC Name: (2R,3S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylpentanoic acid SMILES: CC[C@H](C)[C@@H](NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C12)C(O)=O

PubChem CID 6992517
CAS 118904-37-3
Molecular Weight (g/mol) 353.42
MDL Number MFCD00077062
SMILES CC[C@H](C)[C@@H](NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C12)C(O)=O
Synonym fmoc-d-allo-ile-oh,fmoc-d-allo-isoleucine,fmoc-d-allo-lle-oh,2r,3s-n-fmoc-2-amino-3-methylpentanoic acid,2r,3s-2-9h-fluoren-9-yl methoxy carbonyl amino-3-methylpentanoic acid,d-alloisoleucine, n-9h-fluoren-9-ylmethoxy carbonyl,2r,3s-2-9h-fluoren-9-ylmethoxy carbonyl amino-3-methylpentanoic acid,ambotzfaa1328,pubchem15619
IUPAC Name (2R,3S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylpentanoic acid
InChI Key QXVFEIPAZSXRGM-KINVLMLONA-N
Molecular Formula C21H23NO4
8

L-Isoleucine methyl ester hydrochloride, 98+%, Thermo Scientific Chemicals

CAS: 18598-74-8 Molecular Formula: C7H16ClNO2 Molecular Weight (g/mol): 181.66 MDL Number: MFCD00038911 InChI Key: GGTBEWGOPAFTTH-GEMLJDPKSA-N Synonym: l-isoleucine methyl ester hydrochloride,h-ile-ome.hcl,methyl l-isoleucinate hydrochloride,methyl l-isoleucinate hcl,methyl 2s,3s-2-amino-3-methylpentanoate hydrochloride,2s,3s-methyl 2-amino-3-methylpentanoate hydrochloride,l-isoleucine, methyl ester, hydrochloride,l-isoleucine methyl ester hydrochloride;h-ile-ome.hcl,h-lle-ome.hcl,h-lle-ome?cl PubChem CID: 11171351 IUPAC Name: methyl (2S,3S)-2-amino-3-methylpentanoate;hydrochloride SMILES: Cl.CC[C@H](C)[C@H](N)C(=O)OC

PubChem CID 11171351
CAS 18598-74-8
Molecular Weight (g/mol) 181.66
MDL Number MFCD00038911
SMILES Cl.CC[C@H](C)[C@H](N)C(=O)OC
Synonym l-isoleucine methyl ester hydrochloride,h-ile-ome.hcl,methyl l-isoleucinate hydrochloride,methyl l-isoleucinate hcl,methyl 2s,3s-2-amino-3-methylpentanoate hydrochloride,2s,3s-methyl 2-amino-3-methylpentanoate hydrochloride,l-isoleucine, methyl ester, hydrochloride,l-isoleucine methyl ester hydrochloride;h-ile-ome.hcl,h-lle-ome.hcl,h-lle-ome?cl
IUPAC Name methyl (2S,3S)-2-amino-3-methylpentanoate;hydrochloride
InChI Key GGTBEWGOPAFTTH-GEMLJDPKSA-N
Molecular Formula C7H16ClNO2
9

N-Acetyl-L-isoleucine, 98%, Thermo Scientific Chemicals

CAS: 3077-46-1 Molecular Formula: C8H15NO3 Molecular Weight (g/mol): 173.21 MDL Number: MFCD00066072 InChI Key: JDTWZSUNGHMMJM-IFSCUNPJNA-N Synonym: n-acetyl-l-isoleucine,2s,3s-2-acetamido-3-methylpentanoic acid,ac-ile-oh,l-isoleucine, n-acetyl,unii-p9cl0y0bvz,p9cl0y0bvz,isoleucine, n-acetyl-, l,acetyl isoleucine,n-acetyl-isoleucine,acetyl-l-isoleucine PubChem CID: 7036275 ChEBI: CHEBI:21555 SMILES: CC[C@H](C)[C@H](NC(C)=O)C(O)=O

PubChem CID 7036275
CAS 3077-46-1
Molecular Weight (g/mol) 173.21
ChEBI CHEBI:21555
MDL Number MFCD00066072
SMILES CC[C@H](C)[C@H](NC(C)=O)C(O)=O
Synonym n-acetyl-l-isoleucine,2s,3s-2-acetamido-3-methylpentanoic acid,ac-ile-oh,l-isoleucine, n-acetyl,unii-p9cl0y0bvz,p9cl0y0bvz,isoleucine, n-acetyl-, l,acetyl isoleucine,n-acetyl-isoleucine,acetyl-l-isoleucine
InChI Key JDTWZSUNGHMMJM-IFSCUNPJNA-N
Molecular Formula C8H15NO3
10

L-allo-Isoleucine, 99%, 99% ee, Thermo Scientific Chemicals

CAS: 1509-34-8 Molecular Formula: C6H13NO2 Molecular Weight (g/mol): 131.18 MDL Number: MFCD00066446 InChI Key: AGPKZVBTJJNPAG-BJNJOQLTNA-N Synonym: l-allo-isoleucine,l-alloisoleucine,alloisoleucine,2s,3r-2-amino-3-methylpentanoic acid,allo-isoleucine,allo-l-isoleucine,h-allo-ile-oh,3r-ls-isoleucine,isoleucine, allo,isoleucine, threo PubChem CID: 99288 ChEBI: CHEBI:43433 IUPAC Name: (2S,3R)-2-amino-3-methylpentanoic acid SMILES: CC[C@@H](C)[C@H](N)C(O)=O

PubChem CID 99288
CAS 1509-34-8
Molecular Weight (g/mol) 131.18
ChEBI CHEBI:43433
MDL Number MFCD00066446
SMILES CC[C@@H](C)[C@H](N)C(O)=O
Synonym l-allo-isoleucine,l-alloisoleucine,alloisoleucine,2s,3r-2-amino-3-methylpentanoic acid,allo-isoleucine,allo-l-isoleucine,h-allo-ile-oh,3r-ls-isoleucine,isoleucine, allo,isoleucine, threo
IUPAC Name (2S,3R)-2-amino-3-methylpentanoic acid
InChI Key AGPKZVBTJJNPAG-BJNJOQLTNA-N
Molecular Formula C6H13NO2
11

L-Isoleucine ethyl ester hydrochloride, 98%, Thermo Scientific Chemicals

CAS: 56782-52-6 Molecular Formula: C8H18ClNO2 Molecular Weight (g/mol): 195.69 MDL Number: MFCD09953729 InChI Key: QQGRWNMNWONMOO-LEUCUCNGSA-N Synonym: l-isoleucine ethyl ester hydrochloride,h-ile-oet.hcl,ethyl l-isoleucinate hydrochloride,l-isoleucine ethyl ester hcl,2s,3s-ethyl 2-amino-3-methylpentanoate hydrochloride,isoleucine, ethyl ester, hydrochloride,ethyl 2s,3s-2-amino-3-methylpentanoate hydrochloride,l-isoleucine ethylester hcl,ksc497o6p,l-isoleucineethylesterhydrochloride PubChem CID: 6453390 SMILES: Cl.CCOC(=O)[C@@H](N)[C@@H](C)CC

PubChem CID 6453390
CAS 56782-52-6
Molecular Weight (g/mol) 195.69
MDL Number MFCD09953729
SMILES Cl.CCOC(=O)[C@@H](N)[C@@H](C)CC
Synonym l-isoleucine ethyl ester hydrochloride,h-ile-oet.hcl,ethyl l-isoleucinate hydrochloride,l-isoleucine ethyl ester hcl,2s,3s-ethyl 2-amino-3-methylpentanoate hydrochloride,isoleucine, ethyl ester, hydrochloride,ethyl 2s,3s-2-amino-3-methylpentanoate hydrochloride,l-isoleucine ethylester hcl,ksc497o6p,l-isoleucineethylesterhydrochloride
InChI Key QQGRWNMNWONMOO-LEUCUCNGSA-N
Molecular Formula C8H18ClNO2
13

L-Isoleucine tert-butyl ester hydrochloride, 98%, Thermo Scientific Chemicals

CAS: 69320-89-4 Molecular Formula: C10H22ClNO2 Molecular Weight (g/mol): 223.74 MDL Number: MFCD00058015 InChI Key: IFRYMHOZFAPYPJ-HAGKNZRZNA-N Synonym: h-ile-otbu.hcl,l-isoleucine tert-butyl ester hydrochloride,h-ile-otbu hcl,l-isoleucine t-butyl ester hydrochloride,h-ile-otbu hydrochloride,l-isoleucine t-butyl ester hcl,tert-butyl 2s,3s-2-amino-3-methylpentanoate hydrochloride,l-isoleucine, 1,1-dimethylethyl ester, hydrochloride,h-ile-obut.hcl,h-ile-otbu??hcl PubChem CID: 11687228 IUPAC Name: tert-butyl (2S,3S)-2-amino-3-methylpentanoate;hydrochloride SMILES: Cl.CC[C@H](C)[C@H](N)C(=O)OC(C)(C)C

PubChem CID 11687228
CAS 69320-89-4
Molecular Weight (g/mol) 223.74
MDL Number MFCD00058015
SMILES Cl.CC[C@H](C)[C@H](N)C(=O)OC(C)(C)C
Synonym h-ile-otbu.hcl,l-isoleucine tert-butyl ester hydrochloride,h-ile-otbu hcl,l-isoleucine t-butyl ester hydrochloride,h-ile-otbu hydrochloride,l-isoleucine t-butyl ester hcl,tert-butyl 2s,3s-2-amino-3-methylpentanoate hydrochloride,l-isoleucine, 1,1-dimethylethyl ester, hydrochloride,h-ile-obut.hcl,h-ile-otbu??hcl
IUPAC Name tert-butyl (2S,3S)-2-amino-3-methylpentanoate;hydrochloride
InChI Key IFRYMHOZFAPYPJ-HAGKNZRZNA-N
Molecular Formula C10H22ClNO2
14

N-Fmoc-N-methyl-L-isoleucine, 95%, Thermo Scientific Chemicals

CAS: 138775-22-1 Molecular Formula: C22H25NO4 Molecular Weight (g/mol): 367.45 MDL Number: MFCD00153389 InChI Key: IQIOLCJHRZWOLS-DZLYFNQKNA-N Synonym: fmoc-n-me-ile-oh,fmoc-n-methyl-l-isoleucine,fmoc-n-me-lle-oh,n-fmoc-n-methyl-l-isoleucine,n-alpha-9-fluorenylmethyloxycarbonyl-n-alpha-methyl-l-isoleucine,2s,3s-2-9h-fluoren-9-ylmethoxy carbonyl methyl amino-3-methylpentanoic acid,fmoc-melle-oh,fmoc-l-meile-oh,ambotzfaa1398,pubchem18966 PubChem CID: 15433034 IUPAC Name: (2S,3S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-methylpentanoic acid SMILES: CC[C@H](C)[C@H](N(C)C(=O)OCC1C2=CC=CC=C2C2=CC=CC=C12)C(O)=O

PubChem CID 15433034
CAS 138775-22-1
Molecular Weight (g/mol) 367.45
MDL Number MFCD00153389
SMILES CC[C@H](C)[C@H](N(C)C(=O)OCC1C2=CC=CC=C2C2=CC=CC=C12)C(O)=O
Synonym fmoc-n-me-ile-oh,fmoc-n-methyl-l-isoleucine,fmoc-n-me-lle-oh,n-fmoc-n-methyl-l-isoleucine,n-alpha-9-fluorenylmethyloxycarbonyl-n-alpha-methyl-l-isoleucine,2s,3s-2-9h-fluoren-9-ylmethoxy carbonyl methyl amino-3-methylpentanoic acid,fmoc-melle-oh,fmoc-l-meile-oh,ambotzfaa1398,pubchem18966
IUPAC Name (2S,3S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-methylpentanoic acid
InChI Key IQIOLCJHRZWOLS-DZLYFNQKNA-N
Molecular Formula C22H25NO4
15

L-Isoleucine, Multi-Compendial, U.S.P., J.T. Baker™

CAS: 73-32-5 Molecular Formula: C6H13NO2 Molecular Weight (g/mol): 131.18 MDL Number: MFCD00064222 MFCD00004268 InChI Key: AGPKZVBTJJNPAG-WHFBIAKZSA-N Synonym: l-isoleucine,isoleucine,2s,3s-2-amino-3-methylpentanoic acid,s-isoleucine,s,s-isoleucine,2s,3s-isoleucine,2-amino-3-methylvaleric acid,erythro-l-isoleucine,l-+-isoleucine,l-ile PubChem CID: 6306 ChEBI: CHEBI:17191 IUPAC Name: (2S,3S)-2-amino-3-methylpentanoic acid SMILES: CC[C@H](C)[C@H](N)C(O)=O

PubChem CID 6306
CAS 73-32-5
Molecular Weight (g/mol) 131.18
ChEBI CHEBI:17191
MDL Number MFCD00064222 MFCD00004268
SMILES CC[C@H](C)[C@H](N)C(O)=O
Synonym l-isoleucine,isoleucine,2s,3s-2-amino-3-methylpentanoic acid,s-isoleucine,s,s-isoleucine,2s,3s-isoleucine,2-amino-3-methylvaleric acid,erythro-l-isoleucine,l-+-isoleucine,l-ile
IUPAC Name (2S,3S)-2-amino-3-methylpentanoic acid
InChI Key AGPKZVBTJJNPAG-WHFBIAKZSA-N
Molecular Formula C6H13NO2