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Invitrogen™ TNIK Polyclonal Antibody

Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA582456
This item is not returnable.
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Description
Immunogen sequence: QGPALTASQS VHEQPTKGLS GFQEALNVTS HRVEMPRQNS DPTSENPPLP TRIEKFDRSS WLRQEEDIPP KVPQRTTSIS PALARKNSPG NGSALGPRLG SQPIRASNPD LRRTEPILES PLQRTSSGSS SSSS Highest antigen sequence indentity to the following orthologs: Mouse - 99%, Rat - 99%.
TNIK or TRAF2 and NCK interacting kinase is characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function. TNIK is mainly expression in brain, heart, and spleen and it is a specific effector of RAP2 which regulate actin cytoskeleton. TNIK is autophosphorylated in a manner dependent upon lys54 in the ATP-binding pocket of its kinase domain and plays a main role in cytoskeleton regulation. TNIK has also been shown to phosphorylate gelsolin, the principal intracellular and extracellular actin-severing protein, in vitro. This and evidence from mutational studies suggest that TNIK functions in the regulation of the cytoskeleton.
Specifications
| TNIK | |
| Polyclonal | |
| Unconjugated | |
| TNIK | |
| 1500031A17Rik; 4831440I19Rik; AI451411; C530008O15Rik; C630040K21Rik; KIAA0551; RGD1561817; Tnik; TRAF2 and NCK interacting kinase; TRAF2 and NCK-interacting protein kinase | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 23043 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Immunocytochemistry | |
| 0.1 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q9UKE5 | |
| TNIK | |
| Recombinant protein corresponding to Human TNIK. Recombinant protein control fragment (Product #RP-89795). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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