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Tocris Bioscience™ TM2 TEAD inhibitor
Potent and reversible inhibitor of TEAD mediated Hippo/Yap signalling
€ 157.00 - € 589.00
Specifications
| Chemical Name or Material | 4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide |
|---|---|
| CAS | 1008768-41-9 |
| Target | YAP1 |
| Molecular Formula | C26H33N3O3 |
| Purity | 0.98 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18706075
|
Tocris Bioscience™
7917/10 |
10 mg |
€ 157.00
10mg |
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|
18705925
|
Tocris Bioscience™
7917/50 |
50 mg |
€ 589.00
50mg |
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Description
TM2 TEAD inhibitor is a potent and reversible TEA domain transcription factor inhibitor (IC50 = 38 nM and 156 nM for TEAD4 auto-palmitoylation and TEAD2 palmitoylation, respectively). It inhibits TEAD-YAP association and transcriptional activity. TM2 TEAD inhibitor exhibits strong antiproliferation effects as a single agent or in combination with a MEK inhibitor in YAP-dependent cancer cells. Also inhibits YAP-dependent liver organoid growth ex vivo.Specifications
| 4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide | |
| YAP1 | |
| 0.98 |
| 1008768-41-9 | |
| C26H33N3O3 |
Safety and Handling
Recommended Storage : Store at -20°C
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