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Tocris Bioscience™ Temsirolimus
mTOR inhibitor; antitumor
Brand: Tocris Bioscience™ 5264/10
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Description
Temsirolimus is a mTOR inhibitor; inhibits tumor growth in breast cancer cell lines (IC50 values are 1.6 and 4.3 nM for SKBr3 and BT474, respectively). Inhibits HIF-1α-mediated VEGF production in breast cancer cell lines (BT474 and MDA-MB-231). Directly inhibits serum and VEGF mediated endothelial cell proliferation and morphogenesis in vitro and vessel formation in vivo. Causes G1/S cell cycle arrest in multiple cancer cell lines. Antiangiogenic. Activates autophagy.Specifications
| >98% | |
| 10 mg | |
| 1030.29 |
| CCI-779 | |
| Temsirolimus | |
| Temsirolimus |
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