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PPM1A Mouse anti-Human, Monkey, Clone:7F12, Abnova™
Mouse monoclonal antibody raised against recombinant human PPM1A.
Brand: Abnova MAB17729.100ug
This item is not returnable.
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Description
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]Specifications
| PPM1A | |
| Monoclonal | |
| Unconjugated | |
| ELISA (1:10000) Flow Cytometry (1:200-1:400) Immunocytochemistry Immunohistochemistry Western Blot (1:500-1:2000) The optimal working dilution should be determined by the end user. |
|
| PPM1A | |
| Mouse | |
| 100 μg | |
| Human, Monkey | |
| Antibody | |
| IgG1 |
| ELISA, Western Blot | |
| 7F12 | |
| protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform | |
| In PBS (0.05% sodium azide) | |
| FLJ42306, MGC9201, PP2C-ALPHA, PP2CA | |
| Recombinant protein corresponding to amino acids 202-382 of human PPM1A from E. coli. | |
| 5494 | |
| Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing. |
|
| Liquid |