Thermo Scientific™ CT(PEG)12 Carboxy-PEG-Thiol Compound

Description

Thermo Scientific™ Pierce CT(PEG)12, or carboxy-PEG12-thiol, is a carboxyl- and sulfhydryl-terminated compound that contains a 12-unit polyethylene glycol (PEG) spacer and is used to modify surfaces such as quantum dots, monolayers and magnetic particles.

CT(PEG)12 is monodentate thiol-terminated and carboxylic acid pegylation reagent. The PEG compound has a defined molecular weight and spacer length and is useful for modifying surfaces such quantum dots, self-assembled monolayers and magnetic particles. Functionalization of solid surfaces with this polyethylene glycol reagent provides carboxylate “handles“ for protein immobilization via EDC crosslinking and significantly reduces nonspecific protein binding and provides.

Highlights:

• Metal-binding – terminal monodentate thiol reacts spontaneously with gold surfaces through dative binding

• Carboxylate – terminal carboxylic acid group allows conjugation to amine-containing affinity ligands using carbodiimide (EDC) and Sulfo-NHS crosslinking chemistry

• Polyethylene glycol – PEG groups are flexible, non-immunogenic, hydrophilic, and significantly reduce nonspecific binding of surfaces for protein methods

• Spacer arm – 12-unit PEG spacer is nearly 48 angstroms long, minimizing steric hindrance for protein immobilization and binding assays

Specifications:

• Alternative name: Carboxy-PEG12-Thiol
• Chemical name: 1-mercapto-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontan-39-oic acid
• Chemical formula: C27H54O14S
• Molecular weight: 634.77
• Spacer arm: 47.8 angstroms
• Form: colorless to pale yellow liquid
• Solubility: dissolve in DMSO or DMF for use