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Thermo Scientific™ BS(PEG)9

Crosslink amines to amines with these long (21.7A and 35.8A) crosslinkers composed of NHS-ester groups and 5-unit or 9-unit PEG spacer arms that enhance protein solubility.

Brand:  Thermo Scientific™ 21582

Product Code. 10647514

  • € 487.00 / 100mg
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Description

Description

Thermo Scientific™ Pierce BS(PEG)n Crosslinkers include BS(PEG)5 and BS(PEG)9, which are bis-succinimide ester-activated PEG compounds for crosslinking between primary amines in proteins and other molecules.

BS(PEG)9 is a bis-succinimide ester-activated PEG compound used for crosslinking between primary amines (–NH2) in proteins and other molecules. The N-hydroxysuccinimide ester (NHS) groups at either end of the PEG9 spacer react specifically and efficiently with lysine and N-terminal amino groups at pH 7-9 to form stable amide bonds.

Features of BS(PEG)9:

  • Reactive groups: NHS ester (both ends)
  • Reactive towards: amino groups (primary amines)
  • NHS esters react with –NH2 groups at pH 7-9, forming stable amide bonds
  • Water-soluble; compare to non-pegylated BS3 (also soluble) (Cat. No. 21580) and DSS (water-insoluble) (Cat. No. 21655)
  • Membrane-impermeable, allowing for cell surface labeling
  • Irreversibly crosslink proteins or peptides by flexible PEG spacer arms
  • Polyethylene glycol spacer arms help maintain conjugate solubility
  • Pure compound with defined structure and molecular weight, ensuring reproducible protein-modification effects
  • PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
  • Ideal for small molecule or peptide conjugations

Alternative Names for BS(PEG)n:

  • Bis-NHS-dPEG
  • NHS-PEG-NHS
  • BS(PEO)5
  • Bis(NHS)PEO5
  • BS-PEO9
  • dPEG NHS ester
  • Bis-succinimide ester PEG 400

Product References

  • Crosslinker Application Guide -- search for recent literature references for this product
  • Bioconjugate Techniques, Academic Press (Cat. No. 20036)

Related Products

  • BS(PEG)5 (PEGylated bis(sulfosuccinimidyl)suberate) (Cat. No. 21581)
  • BS3 (bis(sulfosuccinimidyl)suberate) (Cat. No. 21580)
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Amine-Amine
BS(PEG)9
Yes
Upon receipt store desiccated at -20°C.
Ambient
Chemical Labeling
NHS Ester
Liquid
Water
Yes
No
708.71
35.8 Å
No
Pierce™
Homobifunctional
Long (>30 Å)
100 mg
Standard
Crosslinker
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For Research Use Only. Not for use in diagnostic procedures.