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Gibco™ Human TSLP Recombinant Protein, PeproTech®
E. coli Recombinant Protein
Brand: Gibco™ 300-62-10UG
This item is not returnable.
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Description
TSLP is a 159 amino acid four helix-bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain. It impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes, enhances the maturation of CD11c (+) dendritic cells, naive CD4 (+), and CD8 (+) T cells into proallergic effectors, and primes dendritic cells to produce large amounts of IL-12 after CD40 ligand stimulation. TSLP influences the regulation of the positive selection of regulatory T cells and maintenance of peripheral CD4 (+) T cell homeostasis. It induces allergic inflammation by directly activating mast cells and may be involved in the pathophysiology of inflammatory arthritis. It is expressed in heart, liver and prostate.
Specifications
| Q969D9 | |
| protein with no preservative | |
| 15 | |
| 10 μg | |
| -20°C | |
| <1 EU/μg | |
| TSLP | |
| Unconjugated | |
| MYDFTNCDFE KIKAAYLSTI SKDLITYMSG TKSTEFNNTV SCSNRPHCLT EIQSLTFNPTAGCASLAKEM FAMKTKAALA IWCPGYSETQ INATQAMKKR RKRKVTTNKC LEQVSQLQGLWRRFNRPLLK QQ | |
| ≥ 98% by SDS-PAGE gel and HPLC analyses. |
| ELISA, Functional Assay, Western Blot | |
| 85480 | |
| Human TSLP | |
| E. coli | |
| RUO | |
| Thymic stroma-derived lymphopoietin; thymic stromal lymphopoietin; TSLP | |
| Human | |
| Recombinant | |
| Lyophilized |
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