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Invitrogen™ Human SCF Recombinant Protein

Product Code. 11818821
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Quantity:
10 μg
Unit Size:
10µg
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Product Code. 11818821

Brand: Invitrogen™ RSCF10

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This item is not returnable. View return policy

Description

Recombinant Protein

For in vitro applications. A dose-response assay should be performed to determine the optimal concentration for specific experiments. Reconstitution and Dilution: Reconstitute lyophilized material in 0.1 mL of 10 mM Acetic acid to a final concentration of 0.1 mg/mL. Dilute in a buffer-containing carrier protein, aliquot, and store at or below -70°C. Avoid multiple freeze-thaw cycles. PBS with 1% BSA or a neutral media containing <10% FCS are suitable buffers.

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P21583
For Use With (Application) Bioactivity
Formulation 0.01M acetic acid with no preservative
Gene ID (Entrez) 4254
Molecular Weight (g/mol) 18.4 kDa
Name Human SCF
Purification Method Purified
Quantity 10 μg
Source E. Coli
Storage Requirements -20°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias 710-712; blz; c-Kit ligand; Clo; cloud gray; Con; contrasted; CSF; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; Gb; grizzle-belly; hematopoietic growth factor KL; H-SCF; Kit ligand; Kitl; Kitlg; kit-ligand; KL-1; Mast cell growth factor; MGF; M-SCF; Processed kit ligand; SCF; SF; SHEP7; sKITLG; Sl; SLF; Soluble KIT ligand; Steel factor; steel factor/kit ligand; stem cell factor; stem cell factor KL-1; stem cell factor, CSF
Common Name SCF
Gene Symbol KITLG
Biological Activity ED50 < 2 ng/mL; determined by the dose-dependent proliferation of human TF-1 cells.
Product Type Protein
Conjugate Unconjugated
Species E. coli
Recombinant Recombinant
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Activity ED50 < 2 ng/mL; determined by the dose-dependent proliferation of human TF-1 cells.
Expression System E. coli
Form Lyophilized
Protein Subtype Recombinant
Purity or Quality Grade >95%
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