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Proteintech Human BAFF ELISA Kit

BAFF, or B cell-activating factor, also known as B lymphocyte stimulator (BlyS; trademark of Human Genome Sciences, Rockville, MD), TALL‐1, THANK, and TNFSF13B, is a member of the tumor necrosis factor (TNF) superfamily and is best known for its role in the survival and maturation of B cells.

Brand:  Proteintech KE00215-96T


Product Code. 17254876

  • € 269.00 / 96 reactions

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Description

Description

The full-length molecule of BAFF is a 285-amino acid (285 aa) peptide with 2 potential N-glycosylation sites at residues 124 and 242. Cleavage downstream from aa 124 releases a first form of nonglycosylated BAFF, and possibly a second form glycosylated at aa 242. A 152-amino acid form can also be shed from the membrane and is detectable in human serum. Studies on BAFF transgenic mice and patients with rheumatoid diseases indicate that overexpression of BAFF is linked to the development of autoimmune pathology. BAFF expression was detectable in heart, skeletal muscle, pancreas, kidney, skin with adipose tissue, and liver at similar levels as in the CNS.

Specifications

Specifications

10673
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