Recombinant Protein
Brand: Gibco™ PHC9563
Carrier-Free Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute lyophilized recombinant human Activin A in sterile PBS containing 0.1% human serum albumin. Further dilutions should be made in low endotoxin medium or a buffered solution containing a carrier protein such as heat inactivated FCS or tissue culture grade BSA. Storage: Store this lyophilized preparation at <-20°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at <-20°C. Avoid repeated freeze/thaw cycles.
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.
| P08476, Q04998 | |
| PBS with no preservative | |
| 25 kDa | |
| Gel-Purified | |
| <1 EU/mL | |
| Activin A | |
| Unconjugated | |
| Recombinant | |
| Carrier-Free | |
| Inhibition of Proliferation of MPC11 cells | |
| Dry Ice | |
| Growth Factors & Receptors | |
| Lyophilized | |
| Neurobiology, Stem Cell Research, Differentiation | |
| >95% by SDS-PAGE |
| Control, ELISA, Functional Assay, Western Blot | |
| 16323, 3624 | |
| Human Activin A | |
| 1 mg | |
| activin A; activin beta-A chain; BMP7; BMP-7; Bone morphogenetic protein 7; EDF; Eptotermin alfa; erythroid differentiation factor; erythroid differentiation protein; follicle-stimulating hormone-releasing protein; FRP; FSH-releasing protein; INHB; Inhba; inhibin B subunit; inhibin beta A chain; inhibin beta A protein; inhibin beta A subunit; inhibin beta-A; inhibin beta-A-subunit; inhibin beta-subunit; inhibin subunit beta A; inhibin, beta A; inhibin, beta A (activin A, activin AB alpha polypeptide); Inhibin, beta-1; OP1; OP-1; Osteogenic protein 1; unnamed protein product | |
| ED50 = 0.5 - 5 ng/mL; determined by the dose-dependent proliferation of MPC-11 cells. | |
| Human | |
| -20°C | |
| 0.5 ng/ml | |
| <1 EU/ml | |
| HEK293 cells | |
| Recombinant, Ligand | |
| Activins | |
| Gibco™ |
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