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Cytiva HiScreen Capto™ Core 700 Columns
Capto Core 700 is designed for intermediate purification and polishing of viruses and other large biomolecules.
Brand: Cytiva 17-5481-15
This item is not returnable.
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Description
The novel core bead technology and multimodal, octylamine ligand give Capto Core 700 dual functionality, size exclusion, and binding chromatography in one chromatography medium (resin).
- For intermediate purification and polishing of viruses and other large biomolecules (Mr > 700 000) in flowthrough mode.
- Significantly improved productivity and higher flow rates compared with gel filtration methods.
- Straightforward optimization due to flowthrough chromatography and robust performance.
- Convenient small-scale purification, process development, and scale-up using prepacked HiTrap and HiScreen columns.
- Capto Core 700 is composed of a ligand-activated core and inactive shell.
- The inactive shell excludes large molecules (cut off ∼ Mr 700 000 [700 kDa]) from entering the core through the pores of the shell.
- The core of each bead is functionalized with ligands that are both hydrophobic and positively charged, resulting in a highly efficient multimodal binding of various contaminants small enough to enter the core.
- The multimodal ligands ensure strong binding with most impurities over a wide range of pH and salt concentrations.
- Bound impurities are removed from the beads by cleaning-in-place (CIP) procedures using NaOH and in most cases, a solvent.
Specifications
| 1M NaOH, 6M Guanidine Hydrochloride, 30% Isopropanol and 70% Ethanol | |
| 4.7mL | |
| 7.7mm | |
| <500cm/hr. | |
| Octylamine | |
| 2 to 14 | |
| Highly Cross-linked Agarose | |
| Multimodal Column |
| HiScreen Capto Core 700 multimodal column | |
| 0.30 in. | |
| 1 x 4.7mL | |
| Polypropylene | |
| 8 bar | |
| 90μm | |
| 4° to 30°C | |
| Intermediate purification and polishing of viruses and other large biomolecules |
Safety and Handling
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
Supplemental information
- HiScreen Capto
Signal Word
- Warning
Hazard Category
- Flammable liquid Category 3
Hazard Statement
- H226-Flammable liquid and vapour.
Precautionary Statement
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
- P241-Use explosion-proof electrical/ventilating/lighting/ equipment.
- P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
- P235-Keep cool.
- P273-Avoid release to the environment.
- P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
Supplemental information
- MIXTURE LIST-Contains : Ethanol