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Thermo Scientific Chemicals Guanidine hydrochloride, Molecular Biology Grade Product Code.: 15440467
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Thermo Scientific Chemicals Guanidine hydrochloride, Molecular Biology Grade

Product Code. 15440467
500 g
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Quantity:
100 g
500 g
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Product Code. 15440467

Brand: Thermo Scientific Chemicals J65661.36

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Description

A protein denaturant

Guanidine hydrochloride is used for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary. Guanidine hydrochloride is used in RNA isolation to dissociate nucleoproteins and inhibit RNase.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Guanidine hydrochloride is used for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary. Guanidine hydrochloride is used in RNA isolation to dissociate nucleoproteins and inhibit RNase.

Solubility
Freely soluble in water

Notes
Protect from heat. Store away from oxidizing agents.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 50-01-1
Molecular Formula CH6ClN3
Molecular Weight (g/mol) 95.53
MDL Number MFCD00013026
InChI Key PJJJBBJSCAKJQF-UHFFFAOYSA-N
Synonym guanidine hydrochloride, guanidinium chloride, guanidine, monohydrochloride, aminoformamidine hydrochloride, aminomethanamidine hydrochloride, guanidine monohydrochloride, guanidine hcl, guanidine chloride, iminourea hydrochloride, carbamidine hydrochlorideShow MoreShow Less
PubChem CID 5742
ChEBI CHEBI:32735
IUPAC Name guanidine;hydrochloride
SMILES C(=N)(N)N.Cl

Specifications

Melting Point 178°C to 185°C
Color White
Density 1.34
Quantity 500 g
Beilstein 3591990
Sensitivity Hygroscopic
Merck Index 144562
Solubility Information Freely soluble in water
Formula Weight 95.53
Grade Molecular Biology
Physical Form Crystalline Solid
Chemical Name or Material Guanidine hydrochloride
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5 results found
Lot Number Certificate Type Date Catalog Number
Lot NumberX15K002 Certificate TypeCertificate of Analysis Date06/01/2025 Catalog NumberJ65661.22,J65661.36
Lot NumberR10K036 Certificate TypeCertificate of Analysis Date17/05/2024 Catalog NumberJ65661.22,J65661.36
Lot NumberM24K006 Certificate TypeCertificate of Analysis Date31/01/2024 Catalog NumberJ65661.22,J65661.36
Lot NumberU06G001 Certificate TypeCertificate of Analysis Date24/10/2023 Catalog NumberJ65661.22,J65661.36
Lot NumberW27J008 Certificate TypeCertificate of Analysis Date24/10/2023 Catalog NumberJ65661.22,J65661.36

Safety and Handling

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Product Identifier
  • Guanidine hydrochloride, Molecular Biology Grade
 Signal Word
  • Warning
 Hazard Category
  • Acute toxicity Category 4
  • Serious eye damage/eye irritation Category 2
  • Skin corrosion/irritation Category 2
 Hazard Statement
  • H302-Harmful if swallowed.
  • H315-Causes skin irritation.
  • H319-Causes serious eye irritation.
  • H332-Harmful if inhaled.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P312-Call a POISON CENTER/doctor/if you feel unwell.
  • P337+P313-If eye irritation persists: Get medical advice/attention.
 Supplemental information
  • MIXTURE LIST-Contains : guanidine hydrochloride
SDS

RUO – Research Use Only

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