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Gemcitabine hydrochloride, Tocris Bioscience™

Product Code. 30001393
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

DNA synthesis inhibitor

Deoxycytidine analog that inhibits DNA synthesis. Metabolized to form gemcitabine triphosphate (dFdCTP) and gemcitabine diphosphate (dFdCDP). dFdCTD inhibits ribonucleotide reductase causing a reduction in cellular nucleotides. dFdCTP is incorporated in DNA resulting in DNA strand termination. Displays antitumor activity in vitro and in vivo.

Chemical Identifiers

CAS 122111-03-9
Molecular Formula C9H12ClF2N3O4
Molecular Weight (g/mol) 299.659
InChI Key OKKDEIYWILRZIA-OSZBKLCCSA-N
Synonym gemcitabine hcl, 2',2'-difluorodeoxycytidine monohydrochloride, 2'-deoxy-2',2'-difluorocytidine hydrochloride, 2 1h-pyrimidinone, 4-amino-1-2-deoxy-2,2-difluoro-d-erythro-pentofuranosyl
PubChem CID 44558863
ChEBI CHEBI:31647
IUPAC Name 4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydron;chloride
SMILES [H+].C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F.[Cl-]

Specifications

Quantity 10 mg
Formula Weight 299.66
Percent Purity >99%
Chemical Name or Material Gemcitabine hydrochloride
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