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FK 888, Tocris Bioscience™
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Quantity:
10 mg
Description
Selective, high affinity tachykinin NK1 receptor antagonist (Ki = 0.69 nM) that displays 320-fold selectivity for human over rat NK1 receptors. Inhibits substance P-induced contraction of isolated guinea pig trachea (IC50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration.
Specifications
Specifications
| CAS | 138449-07-7 |
| Molecular Formula | C36H36N4O4 |
| Quantity | 10 mg |
| Synonym | d05ukk, n 2-4-hydroxy-1-1-methyl-1h-indol-3-yl carbonyl-l-prolyl-n-methyl-n-phenylmethyl-3-2-naphthyl-l-alaninamide, l-alaninamide, trans-4-hydroxy-1-1-methyl-1h-indol-3-yl carbonyl-l-prolyl-n-methyl-3-2-naphthalenyl-n-phenylmethyl, 2s,4r-4-hydroxy-1-1-methylindole-3-carbonyl-n-2s-1-methyl-phenylmethyl amino-3-naphthalen-2-yl-1-oxopropan-2-yl pyrrolidine-2-carboxamide, 2s,4r-n-2s-1-benzyl methyl amino-3-naphthalen-2-yl-1-oxopropan-2-yl-4-hydroxy-1-1-methylindole-3-carbonyl pyrrolidine-2-carboxamide, 4r-4-hydroxy-1-1-methyl-1h-indol-3-yl carbonyl-l-prolyl-n-methyl-3-2-naphthalenyl-n-phenylmethyl-l-alaninamide, l-alaninamide, 4r-4-hydroxy-1-1-methyl-1h-indol-3-yl carbonyl-l-prolyl-n-methyl-3-2-naphthalenyl-n-phenylmethyl |
| InChI Key | BFNKQTIJVFGCKQ-PDJGWCFMSA-N |
| SMILES | CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O |
| IUPAC Name | (2S,4R)-N-[(2S)-1-[benzyl(methyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-4-hydroxy-1-(1-methylindole-3-carbonyl)pyrrolidine-2-carboxamide |
| Molecular Weight (g/mol) | 588.708 |
| PubChem CID | 107967 |
| Formula Weight | 588.69 |
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