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FGFR3 Mouse anti-Human, CoraLite 488, Clone: 1F3G1, Proteintech
Mouse Monoclonal Antibody
Brand: Proteintech CL488-66954-100UL
This item is not returnable.
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Description
Fibroblast growth factors (FGFs) are polypeptide growth factors involved in a variety of activities including mitogenesis, angiogenesis, and wound healing (PMID: 1847508). The human FGF receptor family, a subfamily of receptor tyrosine kinases (RTKs), comprises of four family members-FGFR1, FGFR2, FGFR3 and FGFR4 (PMID: 23900974). Each receptor contains an extracellular domain with either two or three immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tyrosine kinase domain. FGFR3 binds acidic and basic fibroblast GH and plays a role in bone development and maintenance. Mutations in the FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia. Due to frequent mutations in certain cancers, FGFR3 gene has also been associated with tumor progression.
Specifications
| FGFR3 | |
| Monoclonal | |
| 1000 μg/mL | |
| Mouse | |
| Primary | |
| Human | |
| IgG1 |
| Immunofluorescence | |
| 1F3G1 | |
| CoraLite 488 | |
| 100 μL | |
| 2261 | |
| Liquid |
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