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Thermo Scientific™ EZ-Link™ TFP Ester-PEG4-DBCO
An amine reactive heterobifunctional crosslinker which contains a dibenzylcyclooctyne (DBCO) group for copper-free click chemistry applications. The crosslinker can be used to label a variety of amine containing molecules such as proteins, biomolecules, or small molecules.
Brand: Thermo Scientific™ C20039
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Description
- An amine reactive heterobifunctional crosslinker which contains a dibenzylcyclooctyne (DBCO) group for copper-free click chemistry applications
- The crosslinker can be used to label a variety of amine containing molecules such as proteins, biomolecules, or small molecules
- Once a protein or (bio)molecule is DBCO labeled, it can undergo a copper-free azide-alkyne cycloaddition reaction to form a stable triazole linkage with an azide labeled coupling partner
- Can be used to create diverse conjugates with the biorthogonal coupling between an alkyne and azide (supplied separately)
- The coupling or crosslinking procedure is typically done in two steps
- First, a protein or amine containing molecule is labeled with a DBCO group and excess crosslinker is removed
- Second, an azide containing moiety (prepared independently) is introduced into the same system as the DBCO moiety
- Labeling occurs under biological conditions without the introduction of any additional reagents such as a copper catalyst
- Ragent readily dissolves in water-miscible solvents for dilution into aqueous reaction mixtures
- TFP esters are more hydrolytically stable than NHS esters
Specifications
| Amine-Azide | |
| TFP Ester-PEG4-DBCO | |
| Yes | |
| Upon receipt store desiccated at -20°C. | |
| Wet Ice | |
| Chemical Labeling | |
| TFP Ester, DBCO | |
| Solid | |
| DMF, DMSO | |
| No |
| No | |
| 714.7 | |
| 17.9 Å | |
| Not determined | |
| EZ-Link™ No-Weigh™ | |
| Heterobifunctional | |
| Medium (10 to 30 Å) | |
| 10 x 1 mg | |
| Standard, Single-use | |
| Crosslinker |