Epiandrosterone, 99%, Thermo Scientific Chemicals

General Description

• Epiandrosterone is a steroid hormone, derived from 5 α-androstane

• It is a dehydroepiandrosterone metabolite and an androgen

• It is a precursor of testosterone and estradiol with hypolipidemic and anabolic activities

Applications

• Epiandrosterone presents some neurological activity since it can bind to the ɣ-aminobutyric acid (GABA)/benzodiazepine-receptor complex (GABA-RC), acting as a negative non-competitive modulator of GABA-RC, and signaling through the N-methyl-D-aspartate receptor

• It can also inhibit the pentose phosphate pathway, dilating blood vessels pre-contracted by partial depolarization

• Epiandrosterone can inhibit the thromboxane A2 synthesis in activated platelets, decrease plasma plasminogen activator inhibitor type 1, reduce tissue plasminogen activator antigen, improve insulin-like growth factor 1 serum levels, and increase the synthesis of cyclic guanosine monophosphate and nitric oxide

• In vitro assays demonstrate that this compound inhibits Junin virus replication vitro anti-adenovirus (AdV) activity

• Epiandrosterone affects glucose oxidation and interleukin-1 beta in in vitro pancreatic islets