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Eeyarestatin I, Tocris Bioscience™

Product Code. 18014892
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Quantity:
10 mg
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This item is not returnable. View return policy

Description

Potent inhibitor of ER-associated protein degradation and translocation

Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). Specifically targets the p97-associated deubiquitinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the proapoptotic protein NOXA. Also enhances adeno-associated viral transduction in multiple cells types.

Specifications

CAS 412960-54-4
Molecular Formula C27H25Cl2N7O7
Quantity 10 mg
Synonym 3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5, 5-dimethyl-2-oxo-1-imidazolidineacetic acid 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
Formula Weight 630.44
Percent Purity >98%
Chemical Name or Material Eeyarestatin I
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