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DL-Thioctic acid, 98%, Thermo Scientific™ Product Code.: 11321687
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DL-Thioctic acid, 98%, Thermo Scientific™

Product Code. 11321687
5g
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Quantity:
5g
25g
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Product Code. 11321687

Brand: Thermo Scientific Alfa Aesar L04711.06

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Description

DL-Thioctic acid, CAS # 1077-28-7, is an antioxidant and coenzyme important for the activity of enzymes.

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General Description

• DL-Thioctic acid derives from octanoic acid, and it has been described as an antioxidant coenzyme important for the activity of enzyme complexes including pyruvate dehydrogenase and glycine decarboxylase

Application

• DL-Thioctic acid has been used in in vivo studies to increase insulin sensitivity and stimulate glucose uptake into adipose and muscle cells in vitro

• DL-Thioctic acid has an essential role in aerobic metabolism

• It has been used as free radical scavenger compound

• It can also assist in repairing oxidative damage via the increase of endogenous antioxidants, including vitamins C, vitamin E, and glutathione

• It can induce apoptosis through caspase-independent and caspase-dependent pathways, a process mediated by intracellular Ca2+

• DL-Thioctic acid has the ability to impact various cellular biological pathways since it can increase glutathione synthesis and modulate transcription factor activity, mainly nuclear factor kappa B (NF-κB)

• It can decrease the phagocytosis of myelin by macrophages

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1077-28-7
Molecular Formula C8H14O2S2
Molecular Weight (g/mol) 206.32
MDL Number MFCD00005474
InChI Key AGBQKNBQESQNJD-UHFFFAOYNA-N
Synonym dl-thioctic acid, thioctic acid, alpha-lipoic acid, 5-1,2-dithiolan-3-yl pentanoic acid, dl-alpha-lipoic acid, 1,2-dithiolane-3-pentanoic acid, 6,8-thioctic acid, thioctacid, 6-thioctic acid, alpha lipoic acidShow MoreShow Less
PubChem CID 864
ChEBI CHEBI:16494
IUPAC Name 5-(1,2-dithiolan-3-yl)pentanoic acid
SMILES OC(=O)CCCCC1CCSS1

Specifications

Boiling Point 160°C to 165°C
Quantity 5g
Beilstein 81853
Merck Index 14,9326
Solubility Information Soluble in methanol,ethanol,diethyl ether and chloroform. Insoluble in water.
Formula Weight 206.33
Percent Purity 98%
Chemical Name or Material DL-Thioctic acid

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5 results found
Lot Number Certificate Type Date Catalog Number
Lot Number10244030 Certificate TypeCertificate of Analysis Date13/10/2022 Catalog NumberL04711.003,L04711.14,L04711.06
Lot Number10236423 Certificate TypeCertificate of Analysis Date07/12/2021 Catalog NumberL04711.003,L04711.14,L04711.06
Lot Number10189417 Certificate TypeCertificate of Analysis Date06/12/2021 Catalog NumberL04711.003,L04711.14,L04711.06
Lot Number5005P22Q Certificate TypeCertificate of Analysis Date06/12/2021 Catalog NumberL04711.003,L04711.14,L04711.06
Lot NumberF18S049 Certificate TypeCertificate of Analysis Date06/12/2021 Catalog NumberL04711.003,L04711.14,L04711.06

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