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  6. Diclofenac sodium salt, Thermo Scientific Chemicals

Diclofenac sodium salt, Thermo Scientific Chemicals

Product Code. 15484939
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Quantity:
5 g
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Standard NSAID and cyclooxygenase (COX) inhibitor

Oxidation of diclofenac sodium produces the metabolite 4'-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Oxidation of diclofenac sodium produces the metabolite 4′-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4′-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.

Solubility
Soluble in water (50 mg/ml), PBS pH 7.2 (6 mg/ml), ethanol (∼35 mg/ml), DMF (∼35 mg/ml), DMSO (∼35 mg/ml), methanol (>24 mg/ml), and acetone (6 mg/ml).

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 15307-79-6
Molecular Formula C14H10Cl2NNaO2
Molecular Weight (g/mol) 318.129
MDL Number MFCD00082251
InChI Key KPHWPUGNDIVLNH-UHFFFAOYSA-M
Synonym diclofenac sodium, sodium diclofenac, diclofenac sodium salt, voltaren, solaraze, anthraxiton, prophenatin, allvoran, batafil, delimon
PubChem CID 5018304
ChEBI CHEBI:4509
IUPAC Name sodium;2-[2-(2,6-dichloroanilino)phenyl]acetate
SMILES C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]

Specifications

Melting Point 283°C to 285°C
Color White
Quantity 5 g
UN Number UN2811
Merck Index 14,3081
Solubility Information Soluble in water to 50mg/ml.
Formula Weight 318.14
Physical Form Powder
Chemical Name or Material Diclofenac sodium salt

Safety and Handling

compliance-icons
Product Identifier
  • Diclofenac sodium salt
 Signal Word
  • Danger
 Hazard Category
  • Acute toxicity Category 3
 Hazard Statement
  • H301-Toxic if swallowed.
 Precautionary Statement
  • P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
 Supplemental information
  • MIXTURE LIST-Contains : Diclofenac sodium salt

RUO – Research Use Only

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