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D 4476, Tocris Bioscience™

Product Code. 18033892
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Selective CK1 inhibitor. Also inhibits TGF-βRI

Selective inhibitor of casein kinase 1 (CK1) and TGF-β type-I receptor (ALK5) that displays > 20-fold selectivity over SAPK2/p38 and a much greater selectivity over all other protein kinases tested. Suppresses site-specific phosphorylation and nuclear exclusion of FOXO1a.

Chemical Identifiers

CAS 301836-43-1
Molecular Formula C23H18N4O3
Molecular Weight (g/mol) 398.422
InChI Key DPDZHVCKYBCJHW-UHFFFAOYSA-N
Synonym ck1 inhibitor, casein kinase i inhibitor, d4476, casein kinase i inhibitor, 4-4-2,3-dihydrobenzo 1,4 dioxin-6-yl-5-pyridin-2-yl-1h-imidazol-2-yl benzamide, 4-4-2,3-dihydrobenzo b 1,4 dioxin-6-yl-5-pyridin-2-yl-1h-imidazol-2-yl benzamide, benzamide,4-4-2,3-dihydro-1,4-benzodioxin-6-yl-5-2-pyridinyl-1h-imidazol-2-yl, 4-4-2,3-dihydro-1,4-benzodioxin-6-yl-5-2-pyridinyl-1h-imidazol-2-yl benzamide, insolution casein kinase i inhibitor, d4476, 4-4-2,3-dihydro-1,4-benzodioxin-6-yl-5-pyridin-2-yl-1h-imidazol-2-yl benzamide
PubChem CID 6419753
IUPAC Name 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
SMILES C1COC2=C(O1)C=CC(=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5

Specifications

Quantity 10 mg
Formula Weight 398.41
Percent Purity >99%
Chemical Name or Material D 4476
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