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  6. Cytarabine, 98%, Thermo Scientific Chemicals

Cytarabine, 98%, Thermo Scientific Chemicals

Product Code. 15244774
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Quantity:
100 mg
1 g
5 g
Packaging:
Glass bottle
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Cytarabine, CAS # 147-94-4, is an inhibitor of DNA synthesis that is used as an anticancer and antiviral agent.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Cytarabine is a nucleoside analog that acts as an antileukemic agent
  • Cytarabine becomes cytotoxic following conversion to its triphosphorylated form, which can be incorporated into DNA primers by DNA polymerase alpha
  • Can induce S phase cell cycle arrest and apoptosis in leukemic and neuronal cells

Applications

  • Has been used to study chemotherapeutic regimens in laboratory studies of leukemia
  • Useful for laboratory studies of cytarabine resistance mechanisms
  • At nanomolar concentrations, cytarabine has been seen to induce mitochondrial apoptosis in leukemic cells through upregulation of multiple Bcl-2 family members
  • It can induce neuronal cell death via inducing γ-H2AX phosphorylation in histones, in the absence of double-stranded DNA breaks
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 147-94-4
Molecular Formula C9H13N3O5
Molecular Weight (g/mol) 243.22
InChI Key UHDGCWIWMRVCDJ-CCXZUQQUSA-N
Synonym cytarabine, cytosine arabinoside, ara-c, arabinocytidine, cytosar, arabinosylcytosine, aracytidine, cytarabin, cytarabinoside, tarabine
PubChem CID 6253
ChEBI CHEBI:28680
IUPAC Name 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
SMILES C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O

Specifications

Melting Point 220.0°C
Assay Percent Range 97.5% min. (HPLC)
Packaging Glass bottle
Quantity 100 mg
Merck Index 152781
Solubility Information Solubility in water: soluble. Other solubilities: soluble in dmso, ethanol
Formula Weight 243.22
Percent Purity 98%
Chemical Name or Material Cytarabine

Safety and Handling

compliance-icons compliance-icons
Product Identifier
  • Cytosine beta-D-arabinofuranoside
 Signal Word
  • Warning
 Hazard Category
  • Serious eye damage/eye irritation Category 2
  • Reproductive toxicity Category 2
  • Respiratory sensitiser Category 1
 Hazard Statement
  • H317-May cause an allergic skin reaction.
  • H361d-Suspected of damaging the unborn child.
  • H319-Causes serious eye irritation.
 Precautionary Statement
  • P201-Obtain special instructions before use.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
SDS

RUO – Research Use Only

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