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Tocris Bioscience™ CLP 257
Selective KCC2 activator
Brand: Tocris Bioscience™ 5242/10
Additional Details : CAS : 1181081-71-9 Weight : 0.00970kg
Description
CLP 257 is a selective KCC2 K+-Cl- cotransporter activator (EC50 = 616 nM). Exhibits selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, as well as 55 other receptors. Enhances Cl- transport and increases KCC2 plasma membrane expression in spinal slices with reduced KCC2 function. Alleviates hypersensitivity in rats with peripheral nerve injury.Specifications
| (5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone | |
| 1181081-71-9 | |
| 10 mg |