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CGS 15943, Tocris Bioscience™ Product Code.: 18003872
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CGS 15943, Tocris Bioscience™

Product Code. 18003872
10 mg
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Quantity:
10 mg
50 mg
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Product Code. 18003872

Brand: Tocris Bioscience 1699/10

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Description

Potent adenosine receptor antagonist

CGS 15943 is a potent adenosine receptor antagonist (Ki values are 3.5, 4.2, 16 and 51 nM for human A1, A2A, A2B and A3 receptors respectively). Inhibits the catalytic subunit of the class IB PI3K isoform p110γ (IC50 = 1.1 μM). Blocks HCC and HDAC cell proliferation in vitro via inhibition of the PI3K/Akt pathway; reduces proliferation of ER+ breast cancer cells. Also acts as a BMP-4 mimetic to stimulate osteogenic differentiation. Orally active in vivo.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 104615-18-1
Molecular Formula C13H8ClN5O
Molecular Weight (g/mol) 285.69
MDL Number MFCD01529897
InChI Key MSJODEOZODDVGW-UHFFFAOYSA-N
Synonym 9-chloro-2-2-furyl-1,2,4 triazolo 1,5-c quinazolin-5-imine, 9-chloro-2-furan-2-yl-1,2,4 triazolo 1,5-c quinazolin-5-amine, chembl16687, 9-chloro-2-2-furyl 1,2,4 triazolo 1,5-c quinazolin-5-amine, 1,2,4 triazolo 1,5-c quinazolin-5-amine,9-chloro-2-2-furanyl, 9-chloro-2-2-furanyl-1,2,4 triazolo 1,5-c quinazolin-5-amine, 1,2,4 triazolo 1,5-c quinazolin-5-amine, 9-chloro-2-2-furanyl, acmc-20ddljShow MoreShow Less
PubChem CID 2690
IUPAC Name 9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
SMILES NC1=NC2=CC=C(Cl)C=C2C2=NC(=NN12)C1=CC=CO1

Specifications

Quantity 10 mg
Formula Weight 285.69
Percent Purity >99%
Chemical Name or Material CGS 15943

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