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Thermo Scientific™ CellSensor™ NFκB-bla RA 1 Cell Line
The CellSensor™ NFκB-bla RA-1 cell line contains a beta-lactamase reporter gene under control of the NFκB response element stably integrated into Ramos 1 (RA-1) cells.
Brand: Thermo Scientific™ K1665
This item is not returnable.
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Description
The CellSensor™ NFκB-bla RA-1 cell line contains a beta-lactamase reporter gene under control of the NFκB response element stably integrated into Ramos 1 (RA-1) cells. To construct this cell line, the NFκB -bla construct was transduced into RA-1 cells by lentivirus. Flow cytometry was used to isolate cells responsive to Tumor Necrosis Factor (TNFThis cell line was validated for DMSO tolerance, cell number, stimulation time, substrate loading time, as well as Z' and EC50 concentrations for TNF. The CellSensor™ NFκB-bla RA-1 cell line is responsive to TNFand can be used to probe NFκB signaling pathways, which are involved in the regulation of apoptosis, viral replication, tumorigenesis, inflammation, and various autoimmune diseases. This cell line can be adapted for high-throughput screening for agonists or antagonists with compound libraries. Candidate drugs can be tested for dose response against this cell line. Academic and non-profit customers, please inquire for special pricing.
Specifications
| Cell-based beta lactamase reporter gene | |
| CellSensor™ Cell Lines are shipped on dry ice. Store in liquid nitrogen immediately upon receipt, or thaw for immediate use. | |
| CellSensor™ | |
| TNF alpha, NIK, TLR, I kappa B, IRAK, IKK, NF-kappa B pathway | |
| CellSensor™ |
| Dividing Cells | |
| Cytokines, Signaling Pathway | |
| 1 Vial | |
| Dividing Cells | |
| Signaling Pathway |
For Research Use Only. Not for use in diagnostic procedures.