CD59 Monoclonal Antibody (1F5), Invitrogen™

Description

MA1-70058 detects CD59 in human samples. MA1-70058 has been successfully used in flow cytometry procedures. The MA1-70058 immunogen is Neuraminidase-treated Human Erythrocytes (Neu-HuE). Store at 4oC. For long term storage, alilquot and freeze unused portion at -20oC in single use volumes. Avoid freeze/thaw cycles.

CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). CD59 is the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 also associates with C5b-8 complex and counteracts appropriate formation of cytolytic pore within the plasma membrane. Further, CD59 is a low-affinity ligand of human CD2, causes T cell costimulation, and is involved in lymphocyte signal transduction. CD59 is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. Mutations in this gene cause CD59 deficiency, a disease involving hemolytic anemia, thrombosis, and cerebral infarction. Multiple alternatively spliced transcript variants of CD59 have been identified.