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Calphostin C, Tocris Bioscience™

Product Code. 18084232
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Quantity:
100 μg
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Description

Potent, selective and photo-dependent PKC inhibitor

Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC50 ∽ 40 - 60 nM). Also an antagonist of the Tcf/β-catenin complex.

Specifications

CAS 121263-19-2
Molecular Formula C44H38O14
Quantity 100 μg
Synonym calphostin c, calphostin c, cladosporium cladosporioides, 1-4,9-dihydroxy-12-2-4-hydroxyphenoxycarbonyl oxy propyl-2,6,7,11-tetramethoxy-3,10-dioxoperylen-1-yl propan-2-yl benzoate, carbonic acid, 1r-2-12-2r-2-benzoyloxy propyl-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl-1-methylethyl4-hydroxyphenyl ester, stereoisomer, carbonic acid, 2-12-2-benzoyloxy propyl-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl-1-methylethyl 4-hydroxyphenyl ester, acmc-20d0wl, 1-3,10-dihydroxy-12-2-4-hydroxyphenoxy carbonyl oxy propyl-2,6,7,11-tetramethoxy-4,9-dioxo-4,9-dihydroperylen-1-yl propan-2-yl benzoate, carbonic acid, 1r-2-12-2r-2-benzoyloxy propyl-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl-1-methylethyl 4-hydroxyphenyl ester, stereoisomer, calphostin c from cladosporium cladosporioides hplc , powder, 1r-2-12-2r-2-benzoyloxy propyl-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl-1-methylethylcarbonic acid 4-hydroxyphenyl ester
InChI Key LSUTUUOITDQYNO-UHFFFAOYSA-N
SMILES CC(CC1=C(C(=C2C(=O)C=C(C3=C4C(=CC(=O)C5=C(C(=C(C(=C45)C1=C32)CC(C)OC(=O)OC6=CC=C(C=C6)O)OC)O)OC)OC)O)OC)OC(=O)C7=CC=CC=C7
IUPAC Name 1-[3,10-dihydroxy-12-[2-(4-hydroxyphenoxy)carbonyloxypropyl]-2,6,7,11-tetramethoxy-4,9-dioxoperylen-1-yl]propan-2-yl benzoate
Molecular Weight (g/mol) 790.774
PubChem CID 2533
Formula Weight 790.76
Percent Purity >98%
Chemical Name or Material Calphostin C
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