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  7. BMS 536924, Tocris Bioscience™

BMS 536924, Tocris Bioscience™

Product Code. 30001638
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Dual IR/IGF1R inhibitor

Dual inhibitor of the insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) (IC50 values are 73 and 100 nM respectively). Inhibits receptor autophosphorylation and downstream MEK1/2 and Akt signaling. Induces G1 arrest and apoptosis in ML-1 cells; also inhibits cell proliferation in multiple tumor types. Reverses EMT through the attenuation of Snail mRNA expression in MCF10A cell over expressing IGF1R.

Chemical Identifiers

CAS 468740-43-4
Molecular Formula C25H26ClN5O3
Molecular Weight (g/mol) 479.965
InChI Key UGQMURPIMYALPH-OAQYLSRUSA-N
Synonym s-4-2-3-chlorophenyl-2-hydroxyethyl amino-3-4-methyl-6-morpholino-1h-benzo d imidazol-2-yl pyridin-2 1h-one, 4-2s-2-3-chlorophenyl-2-hydroxyethyl amino-3-4-methyl-6-morpholin-4-yl-3h-1,3-benzodiazol-2-yl-1h-pyridin-2-one
PubChem CID 68925359
IUPAC Name 4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-(4-methyl-6-morpholin-4-yl-1,3-dihydrobenzimidazol-2-ylidene)pyridin-2-one
SMILES CC1=CC(=CC2=C1NC(=C3C(=CC=NC3=O)NCC(C4=CC(=CC=C4)Cl)O)N2)N5CCOCC5

Specifications

Quantity 10 mg
Formula Weight 479.96
Percent Purity >98%
Chemical Name or Material BMS 536924
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