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Tocris Bioscience™ BIRB 796

High affinity and selective p38 kinase inhibitor

Brand: Tocris Bioscience™ 5989/50

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Product Code. 18737196

€ 610.00 / 50mg

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Description

BIRB 796 is a high affinity and selective p38 kinase inhibitor (Kd = 50-100 pM). Exhibits no significant inhibition on a panel of related kinases. Inhibits LPS-induced TNFα production in human PBMCs and whole blood (IC50 values are 21 and 960 nM, respectively). Also inhibits JNK2α2 and c-Raf-1 (IC50 values are 98 nM and 1.4 μM, respectively). Cell permeable.

Specifications

Chemical Name or Material	N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N′-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea
Synonym	Doramapimod
Target	p38 Inhibitors
Formula Weight	527.66

CAS	285983-48-4
Quantity	50 mg
Molecular Formula	C₃₁H₃₇N₅O₃
Purity	0.98

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Tocris Bioscience™ BIRB 796

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