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BI 78D3, Tocris Bioscience™

Product Code. 18065512
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Quantity:
10 mg
50 mg
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Description

Selective, competitive JNK inhibitor

Competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. Inhibits JNK interacting protein 1 (JIP1)-JNK binding (IC50 = 500 nM) and prevents JNK substrate phosphorylation. Blocks JNK-dependent Con A-induced liver damage and restores insulin sensitivity in a mouse model of type II diabetes.

Chemical Identifiers

CAS 883065-90-5
Molecular Formula C13H9N5O5S2
Molecular Weight (g/mol) 379.365
InChI Key QFRLDZGQEZCCJZ-UHFFFAOYSA-N
Synonym 4-2,3-dihydrobenzo b 1,4 dioxin-6-yl-3-5-nitrothiazol-2-yl thio-1h-1,2,4-triazol-5 4h-one, 4-2,3-dihydro-1,4-benzodioxin-6-yl-2,4-dihydro-5-5-nitro-2-thiazolyl thio-3h-1,2,4-triazol-3-one, 4-2,3-dihydro-1,4-benzodioxin-6-yl-3-5-nitro-1,3-thiazol-2-yl sulfanyl-1h-1,2,4-triazol-5-one, 4-2,3-dihydrobenzo b 1,4 dioxin-6-yl-3-5-nitro-thiazol-2-yl thio-1h-1,2,4-triazol-5 4h-one, 4-2,3-dihydro-1,4-benzodioxin-6-yl-5-5-nitro-1,3-thiazol-2-yl sulfanyl-2h-1,2,4-triazol-3-one, bi-78d hplc, 4-2,3-dihydro-1,4-benzodioxin-6-yl-3-5-nitro-1,3-thiazol-2-yl sulfanyl-4,5-dihydro-1h-1,2,4-triazol-5-one, 4-2,3-dihydro-1,4-benzodioxin-6-yl-3-5-nitro-2-thiazolyl thio-1h-1,2,4-triazol-5-one, 4-2,3-dihydro-1,4-benzodioxin-6-yl-5-5-nitro-1,3-thiazol-2-yl sulfanyl-1,2,4-triazol-3-ol, 4-2,3-dihydro-1,4-benzodioxin-6-yl-5-5-nitro-1,3-thiazol-2-yl sulfanyl-4h-1,2,4-triazol-3-ol
PubChem CID 2747117
IUPAC Name 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1H-1,2,4-triazol-5-one
SMILES C1COC2=C(O1)C=CC(=C2)N3C(=O)NN=C3SC4=NC=C(S4)[N+](=O)[O-]

Specifications

Quantity 10 mg
Formula Weight 379.37
Percent Purity >99%
Chemical Name or Material BI 78D3
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