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Tocris Bioscience™ ARN 14494
Potent serine palmitoyltransferase inhibitor
€ 193.00 - € 714.00
Specifications
| Chemical Name or Material | rel-1-[1-[2-[(3 aR,6 AS)-Hexahydrocyclopenta[c]pyrrol-2(1 H)-yl]-2-oxoethyl]-4-piperidinyl]-2,3-dihydro-N-methyl-2-oxo-1 H-indole-5-carboxamide |
|---|---|
| CAS | 1037834-43-7 |
| Target | Other Transferase Inhibitors |
| Molecular Formula | C24H32N4O3 |
| Purity | 0.98 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18718176
|
Tocris Bioscience™
7134/10 |
10 mg |
€ 193.00
10mg |
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|
18765736
|
Tocris Bioscience™
7134/50 |
50 mg |
€ 714.00
50mg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
ARN 14494 is a potent serine palmitoyltransferase inhibitor (IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.Specifications
| rel-1-[1-[2-[(3 aR,6 AS)-Hexahydrocyclopenta[c]pyrrol-2(1 H)-yl]-2-oxoethyl]-4-piperidinyl]-2,3-dihydro-N-methyl-2-oxo-1 H-indole-5-carboxamide | |
| Other Transferase Inhibitors | |
| 0.98 |
| 1037834-43-7 | |
| C24H32N4O3 |
Safety and Handling
Recommended Storage : Store at -20°C
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