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Phospho-Syk (Tyr348) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA538094
This item is not returnable.
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Description
Syk (spleen tyrosine kinase) is a 635 amino acid protein that contains one protein kinase domain and two SH2 domains. One of several members of the protein kinase superfamily, Syk functions as a positive effector of B cell antigen receptor (CD79)-stimulated responses, coupling CD79 with the movement of one calcium ion through one of two phospho-regulated pathways. Via its ability to influence CD79 activity and to control the movement of calicum through the cell, Syk plays an important role in a variety of cellular responses, including differentiation, phagocytosis, proliferation and B cell development. Syk expression is upregulated in T cell lymphoma, suggesting a possible role for Syk in tumorigenesis. Two isoforms of Syk, designated short and long, exist due to alternative splicing events.
Specifications
| Phospho-Syk (Tyr348) | |
| Polyclonal | |
| Unconjugated | |
| SYK | |
| Spleen tyrosine kinase, PROTEIN-TYROSINE KINASE SYK | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 20963, 25155, 6850 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 1 mg/mL | |
| Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P43405, P48025, Q64725 | |
| SYK | |
| A synthetic phosphopeptide derived from human SYK around the phosphorylation site of Tyr348 (E-V-YP-E-S) | |
| 100 μg | |
| Primary | |
| Human, Mouse, Non-human Primate, Rat | |
| Antibody | |
| IgG |
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