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Thermo Scientific Chemicals Amphotericin B, 85% Product Code.: 15535156
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Thermo Scientific Chemicals Amphotericin B, 85%

Product Code. 15535156
1 g
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Quantity:
1 g
5 g
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Product Code. 15535156

Brand: Thermo Scientific Chemicals 455490010

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Description

Amphotericin B, CAS # 1397-89-3, is an antifungal that has been used against fungus caused by protozoan parasites of Leishmania genus.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Amphotericin B is an antibiotic that has antifungal activity and is produced mainly by Streptomyces nodosus

Applications

• It has antifungal activity against fungus caused by protozoan parasites of Leishmania genus by binding to an essential component of the fungal cell membrane and altering cell membrane permeability

• It can suppress bone marrow progenitor cells and induce Actinomycin D(CR001) sensitivity in drug resistant HELA cells in vitro

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1397-89-3
Molecular Formula C47H73NO17
Molecular Weight (g/mol) 924.09
MDL Number MFCD00877763
InChI Key APKFDSVGJQXUKY-ZNVUZQDLSA-N
PubChem CID 134129663
SMILES C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(O)=O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C/C=C\C=C/C=C\C=C/C=C\C=C/2)[C@@H](O)[C@@H](N)[C@@H]1OShow MoreShow Less

Specifications

Type Amphotericin B
Melting Point >170.0°C
Water 10% max.
Quantity 1 g
Solubility Information Solubility in water: insoluble.
IUPAC Name (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19Z,21Z,23Z,25Z,27Z,29Z,31Z,33R,35S,36R,37S)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
Formula Weight 924.09
Percent Purity 85%
Chemical Name or Material Amphotericin B

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5 results found
Lot Number Certificate Type Date Catalog Number
Lot NumberA0458525 Certificate TypeCertificate of Analysis Date20/12/2023 Catalog Number455490050,455490010
Lot NumberA0452452 Certificate TypeCertificate of Analysis Date09/05/2023 Catalog Number455490050,455490010
Lot NumberA0451666 Certificate TypeCertificate of Analysis Date02/05/2023 Catalog Number455490050,455490010
Lot NumberA0392536 Certificate TypeCertificate of Analysis Date14/12/2022 Catalog Number455490050,455490010
Lot NumberA0401281 Certificate TypeCertificate of Analysis Date14/12/2022 Catalog Number455490050,455490010

Safety and Handling

compliance-icons
Product Identifier
  • Amphotericin B
 Signal Word
  • Warning
 Hazard Category
  • Serious eye damage/eye irritation Category 2
  • Skin corrosion/irritation Category 2
  • Specific target organ toxicity Category 3
 Hazard Statement
  • H319-Causes serious eye irritation.
  • H335-May cause respiratory irritation.
  • H315-Causes skin irritation.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
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RUO – Research Use Only

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